An enzyme inhibitor developed by Bruce Hammock, PhD, professor of entomology, and colleagues at University of California (UC), Davis, reduced inflammation in the brains of mice born to mothers with maternal immune activation as described in a study (“Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation”) in PNAS. Inflammation triggered by the enzyme, soluble epoxide hydrolase, is linked to neurodevelopmental disorders in these mice.

“Inhibiting that enzyme stops the inflammation and the development of autism-like and schizophrenia-like symptoms in animal models,” said co-author Kenji Hashimoto, PhD, a professor with the Chiba University Center for Forensic Mental Health, Japan.

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