Some children with autism can present with “allergic-like” symptoms, when there is no obvious elevation in serum level of IgE or chronic urticaria, as expected during a typical histamine reaction. There appears to be non-allergic mast cell activation, most likely in response to environmental and stress triggers, which in turn contributes to inflammation.

In some children with autism, histamine intolerance may be contributing significantly to symptoms generally associated with ASD.

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